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Kai Xia, MD, PhD

Trinity Mother Frances Gastroenterology, Hepatology and Endoscopy



Chief, Dept of Gastroenterology, Hepatology and Endoscopy
Director of Clinical Research
Member of the Institutional Research Board
Member of the Trinity Clinic Board of Directors
Member of the Committee of Development and Growth
Trinity Mother Frances Hospitals and Clinics

Specialty
Gastroenterology and Hepatology

Education
Medical Degree
1999      Harvard Medical School, magna cum laude

Residency
1999–2001     Brigham and Women’s Hospital, Harvard Medical School
                     Internal Medicine

Fellowships
2001-2004     Brigham and Women’s Hospital, Harvard Medical School
                    Gastronenterology/Hepatology

Honors and Awards
1991      John Stauffer Scholar Award, Harvard Medical School, Boston
1998      Liberty Mutual Research Scholar Award, Harvard Medical School
1999      magna cum laude, Harvard Medical School
2003      American Society for Gastrointestinal Endoscopy (ASGE) Recognition
             for an outstanding contribution to the field of gastroenterology at the GI
             Practice Conference
2004      The National Pancreas Foundation Research Award, USA
2004      Ken & Louise Goldberg Junior Faculty Award, Harvard Medical School,
             Brigham and Women’s Hospital, Boston
2004      Distinguished Teaching Scholars Award, Harvard Medical School
2004      American College of Gatroenterology (ACG) Award for an outstanding
             program presentation at the Fourteenth North American Conference of
             Gastroenterology Fellows
2005      The Young Investigator Award in Medicine, Harvard Medical School
2007      Physicians Award in clinical research, Trinity Mother Frances Hospitals
             and Clinics
2007      Physicians Award in innovation, Trinity Mother Frances Hospitals and
             Clinics
2012      Physicians Award in Excellence in Clinical Quality, Trinity Mother Frances
             Hospitals and Clinics

Board Certifications
American Board of Internal Medicine
American Board of Internal Medicine - Gastroenterology

Professional Associations/Affiliations
American Society of Gastrointestinal Endoscopy
Chinese American Medical Society, Past President, Boston Chapter
Member, Crohn’s Colitis Foundation
Member, American Liver Foundation

Appointments
Clinical Associate Professor of Medicine
The University of Texas Southwestern Medical Center

Clinical Associate Professor of Medicine
The University of Texas Health Science Center at Tyler

Clinical Expertise
Dr. Kai Xia obtained her MD and PhD degrees magna cum laude from Harvard Medical School in 1999. She completed her residency in internal medicine and fellowship in gastroenterology/hepatology at the Brigham and Women’s Hospital, a Harvard Medical School teaching hospital in Boston. Following her residency, she became a faculty member and an attending physician at the Harvard Medical School and the Brigham and Women’s Hospital. Dr. Kai actively participated in teaching residents and fellows, attending both inpatient and outpatient services and conducting translational research. She published in multiple prestigious professional journals.

In 2005, Dr. Kai joined the Trinity Mother Frances Hospitals and Clinics as an attending physician. Subsequently she established the health system’s first Liver Clinic which now has instituted a well-established network and collaborations with two major academic centers, Baylor University Medical Center and University of Texas Southwestern Medical Center and their liver transplant programs in Dallas. In 2006, Dr. Kai was named the chief of the Department of Gastroenterology, Hepatology and Endoscopy at Trinity Mother Frances and in 2009 she was elected a member of the Trinity Clinic Board of Directors. She also holds three academic appointments as an associate professor of clinical medicine in the Division of Digestive and Liver Diseases at The University of Texas Southwestern Medical Center; at The University of Texas Health Science Center at Tyler; and as an active community faculty member at the Baylor University Medical Center and the Baylor Regional Transplant Institute.

Her clinical interests include liver diseases, general digestive diseases, women’s digestive health and preventive health. She does clinical consultation in all liver-related diseases and general digestive problems as well as performing screening, diagnostic and therapeutic upper endoscopies and colonoscopies. Dr. Kai Xia strives to provide the best quality and the most efficient patient care.

For our patients’ comment on care provided by Dr. Kai, please visit tmfhc.org/MyLife and watch the videos “My Life, My Health and My Journey”. Besides her clinical activities, she also promotes physician education and participates in national multi-center clinical trials and studies on liver diseases. She hosted the first Gastroenterology and Hepatology Updates in Tyler on April 25, 2009. Dr. Kai invited nationally and internationally distinguished speakers from Harvard Medical School in Boston, Mayo Clinic in Rochester and UT Southwestern Medical School in Dallas to update our regional physicians’ knowledge in the diagnosis and management of commonly encountered gastrointestinal and liver diseases. For the detailed program, please visit website tmfhc.org. Because of her achievements and contribution to the field, Dr. Kai has won awards and recognition from the Harvard Medical School in Boston, American College of Gatroenterology (ACG), American Society for Gastrointestinal Endoscopy (ASGE) and Trinity Mother Frances Hospitals and Clinics.

Scientific Presentations
1   EB virus and nasopharyngeal carcinoma. Invited talk at the International Virology Meeting, Shanghai, China, 1985.
2   Role of protein kinase A in herpes simplex virus replication. Selected oral presentation at the XVI International Herpes Virus Workshop, Montery, California, 1991.
3   Protein kinase A and protein kinase C phosphorylate herpes simplex virus type I major regulatory protein ICP4. Selected oral presentation at the XVII International Herpes Virus Workshop, Edinborough, Scotland, 1992.
4   Proto-oncogene product Raf-1 mediated signal transduction. Selected oral presentation at the X International Annual Meeting on Oncogenes, Frederick, Maryland, 1994.
5   Functional interactions between proto-oncoprotein Raf-1 and the tyrosine kinase Jak 2. Selected oral presentation at the XI International Annual Meeting on Oncogenes, Frederick, Maryland, 1995.
6   Raf-1 tyrosine phosphorylation is regulated by the phosphatase cdc25A. Poster presentation at Keystone Symposia, Lake Tahoe, Nevada, 1997.
7   Understanding the molecular mechanisms by which oncogenic Src and Raf kinases promote colon cancer formation. Poster presentation at Gastroenterology Practice Management Conference, Santa Fe, New Mexico, 2003.
8   Role of oncogenic proteins Raf and Src kinases in colon cancer development. Poster presentation at XIV North American Gastroenterology Fellow Conference, Orlando, Florida, 2004.
9   Fulminant liver failure in a patient with sickle cell intrahepatic cholestasis. Poster presentation at XIV North American Gastroenterology Fellow Conference, Orlando, Florida, 2004.
10 Role of Raf and Src kinases in colon cancer development. Oral Presentation at the Digestive Disease Week International Conference, New Orleans, Louisiana, 2004.

Publications

Original Articles:
1   Xia, K., and Y. Zeng. Labeling anti-human IgA monoclonal antibodies with HRP and their applications in the early diagnosis of Epstein-Barr virus-associated nasopharyngeal carcinoma. Journal of Virology, 1 (8), pp289-293, 1985.
2   Xia, K., and Y. Zeng. A simple and rapid method for screening monoclonal antibodies against human complement C3 and guinea-pig C3. Journal of Medical Lab. Technology, 8 (2), pp141-144, 1985.
3   Xia, K., and Y. Zeng. Establishment of four hybridoma cell lines stably secreting monoclonal antibodies against human IgA. Journal of Oncology, 6 (3), pp368-373, 1986.
4   *K. Xia, *D. C. Pallas, C. Cui, K. Conroy, R. P. Narsimhan, H. Mamon, R. J. Collier, and T. M. Roberts. Interaction of the protein kinase Raf-1 with 14-3-3 proteins. Science, 266, pp126-129, 1994.
5   Xia, K., D. M. Knipe, and N. A. DeLuca. Role of protein kinase A and the serine-rich region of herpes simplex virus type 1 ICP4 in viral replication. Journal of Virology, 70 (2), pp1050-1060, 1996.
6   Xia, K., N. A. DeLuca, and D. M. Knipe. Analysis of phosphorylation sites of herpes simplex virus type 1 ICP4. Journal of Virology, 70 (2), pp1061-1071, 1996.
7   Xia, K., N. K. Mukhopadhyay, R. C. Inhorn, D. L. Barber, P. E. Rose, R. S. Lee, R. P. Narsimhan, A. D. D'Andrea, J. D. Griffin, and T. M. Roberts. The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner. Proc. Natl. Acad. Sci. (USA), 93, pp11681-11686, 1996.
8   Barber, D. L., C. N. Corless, K. Xia, T. M. Roberts, and A. D. D'Andrea. Erythropoietin activates Raf-1 by a Sch-independent pathway in CTLL-EPO-R cells. Blood, 89, pp55-64, 1997.
9   Xia, K., R. S. Lee, R.P. Narsimhan, N. K. Mukhopadhyay, B.A. Neel, and T. M. Roberts. Tyrosine phosphorylation of the proto-oncoprotein Raf-1 is regulated by Raf-1 itself and the phosphatase Cdc25A. Mol. Cell. Bio, 19(7) 4891-4824, 1999.
10 Xia K., Y. A. Shen, R. Sadmuranian, and T.M. Roberts. Role of oncogenic proteins Raf and Src kinases in colon cancer development. Gastroenterology 156 (4)S2 A79, 2004.
11 Drori S, GD Girnun, L. Tou, JD Szwaya, E Mueller, K. Xia, RA Shivadasani, BM Spiegelman. Hic-5 regulates an epithelial program mediated by PPAR-gamma. Genes Dev. 19(3):362-375, 2005.

Clinical Communications:
1   Xia, K., J. R Saltzman, and D. Carr-Lock. Anti-Yo antibody-mediated paraneoplastic cerebellar degeneration in a man with esophageal adenocarcinoma. Medscape General Medicine 5(3), 2003.
2   Xia, K., J. Wolf, S. Friedman, and D. Carr-Lock, Granulomatous tracheo-bronchitis associated with Crhon’s disease. Medscape General Medicine 6(1), 2004.

Reviews:
Xia, K., and Y. Zeng. The prospects of producing specific human monoclonal antibodies via mammalian cell cultures (review article). Medicine Abroad: Microbiology, 6 (1), pp183-186, 1984.

Books:
Xia, K., W. Su, X.-M. Tang, and X.-M. Zhao. National Science Foundation of America. Beijing Press, 1986.

Thesis:
Xia, K., Phosphorylation of the herpes-simplex-virus type I major regulatory protein ICP4. Dissertation, Harvard University, Cambridge, 203pp, 1993.
Xia, K. Activation and regulation of proto-oncoprotein Raf-1 kinase activity (M.D. dissertation), Harvard Medical School, Boston, 97pp, 1999.

Patents:
Xia, K., Y. Zeng and Pi, GH, inventors; Chinese Academy of Medical Sciences, Production of monoclonal antibodies against human IgA, human complement C3 and their applications in the early diagnosis of nasopharyngeal carcinoma, Beijing, China, 1988.
Knipe, DM, Xia, K., DeLuca, NA, inventors; President and Fellows of Harvard College assignee, Method of identifying compounds which modulate herpesvirus infection. US Patent 5,869,234, 1999, Feb. 9